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The new edition of this dictionary includes about 1000 new or revised definitions, an expanded chronology appendix, and a new appendix to over 100 websites on genetic subjects.
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Human genetics --- medische genetica --- genetica
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Human genetics --- medische genetica --- genetica
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Genetics --- Genetics. --- Molecular biology --- genetica --- moleculaire biologie
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Frontiers in Biochip Technology Dr. Wan-Li Xing and Dr. Jing Cheng Frontiers in Biochip Technology serves as an essential collection of new research in the field of biochip technology. This comprehensive collection covers emerging technologies and cutting -edge research in the field of biochip technology, with all chapters written by the international stars of this evolving field. Key topics and current trends in biochip technology covered include: -microarray technology and its applications - microfluidics - drug discovery - detection technology - lab-on-chip technology and bioinformatics. Frontiers in Biochip Technology is an important volume for all biotechnologists, bioengineers, genetic engineers, pharmacological researchers, and general bench researchers who want to be up-to-date on the latest advances in the rapidly growing field of biochip technology. The Editors: Dr. Wan-Li Xing, Tsinghua University School of Medicine, National Engineering Research Center for Beijing Biochip Technology (NERCBBT), and CapitalBio Corporation, Beijing, China Dr. Xing is a Professor at Medical Systems Biology Research Center, Tsinghua University School of Medicine, and also serves as the Executive Deputy Director at NERCBBT, CapitalBio Corporation, a world-leader in biochip research. Dr. Xing has published widely and obtained many patents and applications. Dr. Jing Cheng, Tsinghua University School of Medicine, National Engineering Research Center for Beijing Biochip Technology (NERCBBT), and CapitalBio Corporation, Beijing, China Dr. Jing Cheng is the Cheung Kong Professor at Medical Systems Biology Research Center, Tsinghua University School of Medicine, the Director of NERCBBT and CEO & CTO of CapitalBio. Dr. Cheng developed the world's first system of laboratory-on-a-chip in 1998; this work was featured in the front-cover story of the June 1998 issue of Nature Biotechnology and cited as the breakthrough of the year by Science in the same year. He has been awarded Nanogen's most prestigious award Nano Grant, Distinguished Achievement Award for Overseas Chinese Scholars Returned, China's Science & Technology Award for Outstanding Youth, and Qiushi Technology Transfer Award for Outstanding Youth. Dr. Cheng has published over 90 peer-reviewed papers. In addition, he has obtained over 60 European and U.S. patents and applications.
Human biochemistry --- Pharmacology. Therapy --- Human genetics --- Biotechnology --- medische biochemie --- medische genetica --- farmacologie --- biochemie --- genetica --- toxicologie --- biotechnologie
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Hedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine. This is a timely primer on how a system of cell communication, Hedgehog-GLI signaling, plays a critical role in human disease and thus provides the background for the development of novel and rational therapies.
General embryology. Developmental biology --- Oncology. Neoplasms --- Human genetics --- medische genetica --- genetica --- oncologie --- embryologie (geneeskunde)
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Plasticity is the basis for learning, memory formation and cognition, and the adaptability it affords is essential for normal day-to-day functioning. Many diseases of brain functioning can be described as, or affect, plasticity mechanisms. The goal of Plasticity in the Visual System: From Genes to Circuits is to assemble and integrate the various levels of analysis required to approach a more complete picture of plasticity in the visual system. Researchers with backgrounds varying from systems neuroscience to molecular biology present a coherent picture of visual system plasticity, in which an array of genetic and molecular processes becomes linked with changes in neuronal connectivity, physiological changes, and ultimately, learning behavior. Because of its interdisciplinary view on plasticity, this book will appeal to the wide neuroscience community. Plasticity in the Visual System: From Genes to Circuits will advance discussion in a wide range of fields, including molecular, cellular and systems neuroscience, perceptual psychology, computational modeling and will be of use in graduate level courses and seminars in these areas.
Psychology --- Histology. Cytology --- Human genetics --- Neuropathology --- neurologie --- medische genetica --- genetica --- cytologie --- neuropsychologie --- histologie
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DNA Repair and Human Disease highlights the molecular complexities of a few well-known human hereditary disorders that arise due to perturbations in the fidelity of diverse DNA repair machineries.
Histology. Cytology --- Human genetics --- Medical microbiology, virology, parasitology --- medische microbiologie --- medische genetica --- genetica --- cytologie --- histologie
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Intense study of the enigmatic myc proto-oncogene over the last 20 years has broadened our view of its functions and led to insights into transcriptional regulation as well as cancer etiology, cell proliferation, apoptosis, and organismal development. How can one gene be involved in so many aspects of cellular behavior? Of particular interest is the fact that the Myc protein functions as part of a network (comprising Myc, Max, and Mad proteins) whose specific interactions direct transcriptional activation or repression of a large number of target genes. The chapters in this volume examine both molecular and biological aspects of the Myc/Max/Mad network. Included are contributions concerning the regulation of its expression, the mechanisms underlying its diverse transcriptional activities, the structural bases for its critical interactions, and the nature of its target genes. Other chapters explore the evolution of the network, its role in development and genomic instability, and the evidence for a parallel transcriptional network. Overall, this volume provides a broad and current overview of research on a crucial group of transcription factors.
Human genetics --- Medical microbiology, virology, parasitology --- medische microbiologie --- medische genetica --- genetica
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Since the publication of the first edition sixteen years ago, Inborn Metabolic Diseases - Diagnosis and Treatment has become a classic textbook, indispensable for those involved in the care of children and adults with inborn errors of metabolism, including pediatricians, biochemists, die- th cians, neurologists, internists, geneticists, psychologists, nurses, and social workers. This new 4 edition has been extensively revised. An additional clinician, John Walter, has joined the three other editors, there is a new chapter on neonatal screening, including tandem MS/MS, and several new disorders have been included, for example defects involving the pentose phosphate pathway (polyol metabolism) and disorders of glucose transport. However, the focus of the book remains clinical, describing symptoms and signs at presentation, how to come to a diagnosis and methods for treatment. As with the previous edition, the book can be used in two main ways. If the diagnosis is not known the reader should first refer to Chapter 1. This chapter, which includes a number of algorithms and tables, lists the clinical findings under four main headings: the neonatal period and early infancy; acute presentation in late infancy and beyond; chronic and progressive disease; and specific organ involvement. In addition a list of important symptoms or signs can be found at the end of the chapter which then refers either to the text, a table, a figure, an algorithm, a list of disorders, or a combination of these.
Paediatrics --- Human genetics --- Pathological endocrinology --- Neuropathology --- medische genetica --- hersenen --- endocrinologie --- genetica --- pediatrie
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